• (Senior) Research Associate, Immune Receptor Discovery - AgenTus Therapeutics (Cambridge UK)

    Job Locations UK-Cambridge
    Posted Date 3 weeks ago(3/28/2018 6:51 AM)
  • Overview

    AgenTus is seeking a skilled and self-motivated Research Associate / Senior Research Associate, Immune Receptor Screening to join the growing Immune Receptor Discovery group in Cambridge, UK. The successful candidate will work in a multi-disciplinary team focused on the discovery of receptors (TCRs, CARs) for novel immuno-oncology cell therapy products. This role will support ongoing and future target screening campaigns utilizing our multiple proprietary discovery platforms. This is a fantastic opportunity for a self-motivated team player to apply and further develop their skills and to grow in a dynamic drug discovery environment.


    AgenTus Therapeutics is a biopharmaceutical company, and subsidiary of Agenus Inc, focusing on the discovery, development, and commercialization of breakthrough “living drugs” to advance cures for cancer patients. AgenTus employs naturally-derived and engineered receptors, specifically T Cell Receptors (TCRs) and Chimeric Antigen Receptors (CARs), designed to supercharge human immune effector cells to seek and destroy cancer. AgenTus will also aim to advance adoptive cell therapy formats which would enable off-the-shelf living drugs.


    • Conduct flow cytometry-based immunophenotyping supporting the mammalian display screening platform.
    • Perform immune-receptor characterization through e.g. cell killing assays and reporter cell lines.
    • Contribute to the development of primary cell assays.
    • Contribute to T cell engineering and immune receptor development.
    • Ensure timely delivery of data analysis packages and accurate recording of the sample-to-data process.
    • Responsible for high quality of documentation, laboratory notebooks and protocols.


    • M.Sc. in Cell Biology or Immunology with at least 2 years of relevant work experience obtained preferably in a biotech or pharmaceutical company.


    • Experience in multi-color flow cytometry.
    • Experience with cell staining and/or fluorescence reporter assays.
    • Experience in aseptic cell culture techniques, preferably immune cell culture.
    • Excellent communication skills and demonstrated ability to effectively work with scientists of different disciplines.
    • Excellent organizational and record-keeping skills.
    • Knowledge of immune receptor (TCR, BCR) structure and biology.
    • Experience with general molecular biology techniques (PCR, molecular cloning) would be a plus.
    • Knowledge of tumor immunology would be a plus.
    • Experience with primary cell culture would be a plus.


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