Agenus

  • Scientist Antibody Discovery

    Job Locations UK-Cambridge
    Posted Date 5 months ago(7/23/2018 5:53 AM)
    ID
    2018-1432
    Category
    Research
  • Overview

    Agenus is a pioneer in the emerging field of Immuno-oncology. For two decades, Agenus has been creating and advancing patient-specific anticancer vaccines in the effort to harness the power of the immune system to control or eradicate cancer. We now have a portfolio of innovative approaches that include checkpoint modulators, personalized anticancer vaccines and powerful adjuvants. We are dedicated scientists, researchers, biotechnologists, physicians, and businesspeople working together toward one goal: minimize the burden of cancers and infections by helping the body heal itself through the power of science.

     

    The work we do at Agenus is cutting edge and deeply motivating. We believe passionately in our technology, in our pipeline, and in our responsibility to deliver on the promise of immunology to treat cancer and infectious disease. We provide the opportunity to apply your many talents and develop your career in creative and sometimes unconventional ways. If you are looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

     

    We have an exciting opportunity for a Scientist with a background in Phage display to join our Antibody Discovery team at our new site in Cambridge. This is a state of the art facility located in the centre of Cambridge focused on the development of biopharmaceuticals in Immuno Oncology field. You will be part of a global team, with opportunities to grow with the company.

    Responsibilities

    • Expected to independently carry out phage display campaigns, from naïve selections to affinity maturation.
    • Willingness to take the lead on programme teams as the “antibody expert”, to advise on antibody engineering aspects and to effectively select leads that will lead to drug candidates.
    • Aid in the building of new libraries, both practically and theoretically. Able to build affinity maturation libraries for key candidates.
    • Expected to express and purify lead antibodies to small scale, and to conduct initial binding and biophysical screens. Able to work closely as part of a matrix team to make decisions on the best antibody candidates to take forward.
    • Expected to give regular presentations.
    • Manage all antibody data within the project and collate results.
    • Laboratory based – is willing to take the lead within the laboratory and serve as subject matter expert.
    • Is willing to supervise and mentor 1-2 scientific staff within the phage display group.
    • Maintain a current and accurate laboratory record (lab notebook) of all activities.

    Qualifications

    • MSc with >7 years industrial experience or PhD in a biological science/biochemistry discipline. Experience in an industrial setting is desirable.

     

    Experience

    • Experience in phage display, particularly with ScFv and/or Fab formats. Able to work independently performing selections of antibody formats for a variety of targets.
    • Able to identify and characterise lead clones from phage display campaigns using a variety of assays (RBA, ELISA, Biacore etc) to progress drug discovery programmes.
    • Excellent molecular biology skills: cloning, PCR, sequence analysis.
    • Protein expression and purification on small scale skills are required. Experience in HTS expression and screening of antibodies would be advantageous.
    • Experience with BIAcore and/or Luminex as tools to screen antibodies would be desirable.
    • Experience with affinity maturation of antibody fragments using a variety of techniques.
    • Experience in yeast display or other display technologies would be an advantage.
    • Excellent written and verbal communication skills. Ability to work effectively as part of a multidisciplinary team is essential.
    • Able to present data locally, company-wide and to external collaborators.
    • Strong analytical and critical thinking skills with the ability to interpret complex data.

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