• Research Associate (Senior) - Cell Line Development

    Job Locations UK-Cambridge
    Posted Date 5 months ago(9/20/2018 4:02 PM)
  • Overview

    Agenus is a pioneer in the emerging field of Immuno-oncology. For two decades, Agenus has been creating and advancing patient-specific anticancer vaccines in the effort to harness the power of the immune system to control or eradicate cancer. We now have a portfolio of innovative approaches that include checkpoint modulators, personalized anticancer vaccines and powerful adjuvants. We are dedicated scientists, researchers, biotechnologists, physicians, and businesspeople working together toward one goal: minimize the burden of cancers and infections by helping the body heal itself through the power of science.


    The work we do at Agenus is cutting edge and deeply motivating. We believe passionately in our technology, in our pipeline, and in our responsibility to deliver on the promise of immunology to treat cancer and infectious disease. Our environment fosters innovation and leadership at every level. We encourage people to think and dream big. We provide the opportunity to apply your many talents and develop your career in creative and sometimes unconventional ways. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.


    As a Cell Line Development Research Associate within the Cell Line Development team you will contribute to advancing CLD projects to support the generation of therapeutic biologics.




    • Perform stable cell line development projects in a timely manner. Each project includes construction of expression vectors, transfections, selection of clones, extensive mammalian cell culture, cryopreservation and cell line clonality
    • Data analysis and data recording in electronic lab notebook to insure full traceability
    • Quantification of recombinant proteins
    • Writing working instructions and technical reports
    • Prepare presentations and communicate the results to the team
    • Liaise and coordinate CLD projects with Process Development and Process Analytical groups
    • Optimize, evaluate and implement novel methods and technologies for process improvement
    • Participate at laboratory tasks as maintenance of equipment, ordering
    • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug, GxP compliance, where applicable


    • MSc in molecular biology, biotechnology, biochemistry or related discipline with a few years of relevant preferably industry experience
    • Molecular biology skills (PCR, vector construction, Northern blot)
    • Practical knowledge of working with mammalian cell culture techniques
    • Practical experience in developing stable cell lines is a bonus
    • Experience with automation in cell culture and product analysis (FACS, Octet, Biacore) is highly desirable


    • Ability to work to tight deadlines whilst maintaining a good attention to detail
    • Enjoys some repetition of tasks/projects
    • Good analytical skills
    • Outstanding organizational and multi-tasking skills; ability to manage several projects/cell lines simultaneously and to adjust to changing priorities
    • Ability to work independently and in a team
    • Good communication skills and ability to share experience with others


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